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Creators/Authors contains: "Verheyen, Connor"

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  1. ; ; ; ; ; ; ; ; ; (, Communications Medicine)
  2. ; ; ; ; (, Matter)
    Granular hydrogel matrices have emerged as promising candidates for cell encapsulation, bioprinting, and tissue engineering. How- ever, it remains challenging to design and optimize these materials given their broad compositional and processing parameter space. Here, we combine experimentation and computation to create granular matrices composed of alginate-based bioblocks with controlled structure, rheological properties, and injectability pro- files. A custom machine learning pipeline is applied after each phase of experimentation to automatically map the multidimensional input-output patterns into condensed data-driven models. These models are used to assess generalizable predictability and define high-level design rules to guide subsequent phases of development and characterization. Our integrated, modular approach opens new avenues to understanding and controlling the behavior of complex soft materials. 
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